Apr 20 2010
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Inferring Heterozygosity from SNP data
This looks straightforward.
n = total number of reads aligning to a base
y = total number of reads aligning to a base that match the reference
p = probability that reads match the reference base
Bases with LOD>3 were called SNPs or sites of heterozygosity.
From Bloom et al. (2009) Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays. BMC Genomics vol. 10 (1) pp. 221
